Influence of muscle length on muscle atrophy in the mouse tibialis anterior and soleus muscles
نویسندگان
چکیده
منابع مشابه
Myogenin regulates denervation-dependent muscle atrophy in mouse soleus muscle.
Muscle inactivity due to injury or disease results in muscle atrophy. The molecular mechanisms contributing to muscle atrophy are poorly understood. However, it is clear that expression of atrophy-related genes, like Atrogin-1 and MuRF-1, are intimately tied to loss of muscle mass. When these atrophy-related genes are knocked out, inactive muscles retain mass. Muscle denervation stimulates musc...
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For muscle activation, electrical stimulation with varying frequency was reported to be optimal. However, effects of such patterns are, most often, evaluated at one muscle length only. The purpose of this study is to show the influence of ankle joint angle (i.e. muscle length) on effects of activation history within a tetanic contraction in human tibialis anterior muscle (TA). TA of healthy sub...
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Based on the results of several electrodiagnostic and biomechanical studies, the following classification of muscle dysfunction in spastic hemiplegia is proposed: changes in muscle activation (excess symptoms, e.g., spasticity, and deficit symptoms, e.g., paresis); changes in muscle stiffness; and changes in muscle length. The clinical significance of this classification is that different types...
متن کاملMotoneurones that innervate the rat soleus muscle mature later than those to the tibialis anterior and extensor digitorum longus muscles.
The response of motoneurones that innervate either the soleus or tibialis anterior (TA) and extensor digitorum longus (EDL) muscles to increased locomotor activity or to nerve injury at different stages after birth was examined. Increased locomotor activity of rat pups was induced by daily treatment with L-dopa during the first 12 days after birth, and the number of surviving motoneurones to th...
متن کاملIntravital multiphoton imaging of mouse tibialis anterior muscle
Intravital imaging by multiphoton microscopy is a powerful tool to gain invaluable insight into tissue biology and function. Here, we provide a step-by-step tissue preparation protocol for imaging the mouse tibialis anterior skeletal muscle. Additionally, we include steps for jugular vein catheterization that allow for well-controlled intravenous reagent delivery. Preparation of the tibialis an...
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ژورنال
عنوان ژورنال: Biomedical Research
سال: 2009
ISSN: 1880-313X,0388-6107
DOI: 10.2220/biomedres.30.39